To investigate the relationship between sex chromosor-41 abnormalities and gynecological problems such as amenorrhea, infertility, ambignous genitalis & habitual abortion, we reviewed clinical data and results of chromosomal study in the 40 patients who were referred to genetic laboratory of Department of Obstetrics and Gynecology in Chonbuk National University Hospital.
The total incidence. of sex chromosomal abnormalities was 82.5 %, we reconfirmed that the incidence of sex chromosomal abnormalities in the patients of suspected Klinefelter and Turner´s syndrome was higher than in other gynecological patients.
FSH (111.1 mIU/ml) and LH (41.6 mIU/ml) values in Turner´s syndrome were as high as in postmenopausal woman E2 & Testosterone values were lower than mean in the normal reproductive adults. These data suggested that a severe gonadal dysfunction may occurred in the patients with Turner´s syndrome.
We have got very interesting term pregnancies, two cases were observed in Turner´s syndrome (45, X/46, XX., 45, X), one was in Triple X.
In conclusion, sex chromosomal abnormalities were very important causes of amenorrhea and infertility couples, but the type of sex chromosomal abnormalities could influence the fertility rate.
Therefore, it tell us that cytogenetic study is useful to make a accurate diagnosis and management in gynecologically abnormal patients.
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